Axonal guidance is the process through which axons reach their proper targets in the brain. Researchers hypothesize that the wild-type PTP gene product mediates proper axonal guidance by inactivating the Abl gene product. Which experimental observation would best support this hypothesis?

Question

Biology

Levine

3 October, 19:40

Axonal guidance is the process through which axons reach their proper targets in the brain. Researchers hypothesize that the wild-type PTP gene product mediates proper axonal guidance by inactivating the Abl gene product. Which experimental observation would best support this hypothesis?

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Trinity · Answer 1

Suppression of Abl reduces the severity of abnormal axonal guidance in PTP mutants

Explanation:

Axon guidance is a neural development subfield relating to the mechanism by which neurons send out axons to meet their right targets.

ABL gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes. PTPs are known to signal a number of cellular processes, including cell development, differentiation, mitotic cycle, and oncogenic transformation.

Suppression of Abl reduces the severity of abnormal axonal guidance in PTP mutants.