Describe the factors that impact the ability for a skeletal muscle fiber to reach tetany. How do these factors influence the difference in twitch force as the muscle moves from a single twitch to a state of tetanus?

Tetanus is a very aggressive disease generated by clostridium tetani, this clostridium, which is a bactera, releases a toxin that generates tetanization of the muscle, where it contracts massively and simultaneously, remaining over time, similar to a contracture and very different from synchronized and sporadic contraction that requires locomotion or other physiological contractions.

The Tetanus toxin acts as a toxin for the muscle cells that make up the skeletal muscle fiber, which unfortunately leads to the progressive death of the patient who suffers from it.

In simple words, tetanus generates muscle spasms that are maintained over time, preventing the function of the organ, that is, of the muscles, immobilizing them and prohibiting them from other movements.

Patients who reach the target are affected by the diaphragm that contributes to respiration, therefore many of the tetanized patients die in a similar way to suffocation due to a constant spasm of the diaphragm.

Explanation:

The bacterium is found in sporulated form on the ground or on oxidized surfaces, that is why it is important to sterilize oxidized elements or to decontaminate them, and to apply the antithetical vaccine, which is what prevents them from suffering from said pathology.

In simple words, the great differences between a physiological contraction of muscle fibers and tetanized contractions is the time in which they occur, since tetanization lasts over time and physiological does not, and the power of contraction in tetanization is greater., since the toxin of said bacterium potentiates the ionic channels thus generating an increase in the contractile capacity of the muscle fiber compared to the physiological or health situation.

In order for the toxin to have an effect, the bacteria must leave its sporulated state, release the toxin and the wound must be deep enough for the bacteria to enter the bloodstream, after which the toxin enters the myocytes that are muscle fiber cells intensifying muscle spasms by opening calcium channels in a longer period of time, calcium channels are those found in the REL of myocytes, which act as a reserve for this ion, triggering so that the Z lines of the sarcomeros definitively approach spasmodically by shortening the length of the sarcomero.