Based on the diathesis-stress model, which combination is associated with the highest potential for the development of schizophrenia?

Based on the diathesis-stress model schizophrenia is the result of interaction between environmental and biological/genetic factors. According to this model, when the combination of the predisposition (diathesis) and the stress (biological, social, and psychological stressors) exceeds a threshold, the person will develop a disorder.