Using retosynthetic analysis, complete the synthesis of 2-pentanone from ethanol, proceeding through a keto ester as the synthetic intermediate. g

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Chemistry

Paxton Chang

6 May, 14:06

Using retosynthetic analysis, complete the synthesis of 2-pentanone from ethanol, proceeding through a keto ester as the synthetic intermediate. g

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Jerome Dunn · Answer 1

Step 1:

Esterification:

Butyric Acid is treatet with ethanol in the presence of Acid. The corresponding intermediate formed is Keto Ester (Ethyl Butyrate) and serves as a synthetic intermediate. (Highlighted RED in scheme).

Step 2:

Nucleophilic Substitution Reaction:

The corresponding Ester formed is treated with Methyl Magnesium Bromide. And after hydrolysis 2 - Pentanone is synthesized. The r2 step reaction is shoen belo.