In the context, what does the word issue mean? The title of this story is the big trip up yonder

In the context of "The big trip up yonder," the word "issue" means a problem that must be resolved.

Explanation:

"The big trip up yonder" tells the story of what happened in the USA after the Anti-Gerasone drug was created. This medicine interrupts the aging process of the body, leaving people with their bodies always functional and young. This medicine is very cheap and easily distributed and as the whole society is afraid of aging everyone takes the medicine.

As a result, people can live their lives normally even with advancing age, which allows people to remain fertile throughout their lives. This causes everyone to have many children, which ends up creating a problem of overcrowding in the country. The word "issue" refers to this problem and the need to fix it.