Which demographic change resulted from the transoceanic encounters of the early modern era?

For the answer to the question above, the Iberian middle classes were reduced by twenty percent as a result of emigration to New World colonies.

Eurasian populations were decimated by over fifty percent as a result of the spread of the bubonic plague.

Native American societies slightly increased by ten percent from intermarriage with European conquerors.

Native American societies were reduced by ninety percent as a result of European infectious disease.