What is the most important way the Constitution reflects the concerns of Revolutionaries

Thomas Jefferson said "-That whenever any Form of Government becomes destructive of these ends, it is the right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles, and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness ... it is their right, it is their duty, to throw off such Government, and to provide new Guards for their future security."