Which group in the protestant reformation supported the separation of church and state?

Group of Thomas Jefferson and James Madison in the protestant reformation supported the separation of church and state.

Explanation:

Protestant Reformation, is the reformation which took place in the 16th century in the European country and leaded by Martin Luther and James Colvin. Due to the reformation church was established outside of protestant community which is known as Roman Catholic Church including Methodist and Lutheran.

Martin Luther was a German university professor, priest and head of the protestant community. Catholic, Protestant and (Eastern) Orthodox are three types of christianity. In 18th century John Wesley reformed the church of England.