What do you think were the long term effects of this removal on native Americans?

Indian Removal Act was passed which resulted in the forced displacement of the Native Americans to reservation lands

Explanation:

Due to the belief of Manifest destiny, Americans decided to settle in the west of the Appalachians which was the primary area of the native american tribes like Cherokee, Chickasaw, Choctaw, Muscogee Creek and Seminole peoples. the western tribal land became valuable because it was fertile and congenial for settling. The states which saw them included in such lands pressured the federal Government to enact the Indian removal act. "trail of Tears" is the route in which the native Americans undertook their journey by foot for displacement.

During this move, many dies out of exhaustion, starvation and cold. US gained millions of square miles of territory for settling. Much of the fertile land were used for cotton production and many slaves were employed in the plantations. Thus southern economy ran basically on agriculture and slavery.