What are the advantages and disadvantages the Native Americans had when the early settlers arrived in America?

European settlement had overwhelmingly negative consequences for the Native Americans. Though Native American tribes did occasionally form positive relationships with European settlers, permanent European settlement in America eventually led to disease and displacement. Native Americans did not have immunity to European illnesses and their population was devastated by the (sometimes deliberate) introduction of diseases like for example smallpox. Over time, most surviving tribes were forcibly relocated from their traditional lands to make way for expanding European settlements.