An effect of the voyages of Columbus was that

Other nations in Europe worked to profit from the New World as Spain did.

Explanation:

apex

Columbus and the other European explorers landing in the "new" world caused a massive outbreak of disease due to the lack of acquired immunity held by the native populations in North America.

This biological genocide wiped out a significant amount of the population in the New World making the future conquering of the people relatively easy for the Europeans.