How did differences between the English and American Indian culture lead to conflict

Other events also led to serious problems between the Native Americans and the newcomers. One problem was disease. For example, some of the settlers carried the bacteria that caused smallpox, although they themselves did not get sick. Smallpox had caused deadly epidemics in Europe, but it was unknown to the Indians. Their immune systems had developed no protection against the disease. It killed whole tribes. And smallpox was only one disease brought from Europe. There were others that also infected the Indians.

The first meetings between settlers and Native Americans would follow the same course in almost every European settlement along the East Coast. The two groups would meet as friends. They would begin by trading for food and other goods.

In time, however, something would happen to cause a crisis. Perhaps a settler would demand that an Indian stay off the settler's land. Perhaps someone was killed. Fear would replace friendship.