The factor that has the greatest impact on the eventual destruction of Native Americans' way of life was the development of the

A. Automobile

B. Highway

C. Railroad

D. Steamboat

The factor that has the greatest impact on the eventual destruction of Native Americans' way of life was the development of the C. Railroad. The development of railroads allowed thousands of Americans and US soldiers access to the West in just a few hours. This made it easier for them to take control of the Native Americans' regions.