Within how many days of acquiring or discovering a significant financial interest is the investigator required to submit an updated disclosure to the institution?

Within 30 days.

Explanation:

Investigators are required to disclose all significant financial interests connected with their institutional responsibilities. If investigators acquire or discover any new significant financial interest (for instance, through marriage, purchase or acquisition or inheritance), they must submit an updated disclosure to the institution they work for. The new disclosure shall include information that has not been provided before to the institution.