What was the problem with the location where the settlers of Jamestown landed?

It lead them to start fighting because that wasn't where they were supposed to be

A drought that made growing food crops and finding fresh water difficult led to starvation and the drinking of contaminated water, which, along with the swampy area’s plentiful mosquitoes, contributed to the spread of deadly diseases. The settlers also faced conflict with the indigenous people and they had poor leadership in their community.