Over the centuries, the most effective means of "civilizing" natives to Spanish culture was

(A) the encomienda system.

(B) the mission system.

(C) the distribution of mineral wealth.

(D) military occupation.

Answer: Option (B) is correct.

In past, the well-versed system of "civilizing" inhabitant to Spanish culture was "the mission system". The Spanish missionary attempts to incorporate the inhabitants to the culture were more fruitful than the terms utilized by several Spanish rulers.

Spanish missionaries in the Americas were known as the Catholic missions which were entrenched by the Spanish Empire in region starting from Mexico to ending as far as Chile.