Which of the following is true of both the androgen receptor and a retinoid receptor? More than one answer can be correct.

They are always located in the nucleus.

The receptors' NLS is always exposed.

They can bind steroid ligands.

They can signal at the plasma membrane.

They can undergo a conformational change upon binding of a ligand.

Answer: They are always located in the nucleus.

They can undergo a conformational change upon binding of a ligand.

Explanation: Androgen and retinoid receptors are a class of receptors known as intracellular receptors. They are called intracellular receptors because they are usually located within the nucleus of a cell. Androgen and retinoid receptors are receptors to androgen and retinoid hormones respectively. Androgen is a steroid hormone. Androgen and retinoid hormones are water insoluble hormones that can readily pass through the plasma membrane of a cell through simple diffusion in order to its receptor in the nucleus. Intracellular receptors have two binding site: the ligand binding site and DNA binding site. The binding of the hormone to its receptor triggers a change in conformation that enables the binding of a highly specific DNA sequence to the DNA binding site.