The octameric histone core is comprised of four different histone proteins, assembled in a stepwise manner. Once the core octamer has been formed, DNA wraps around it to form a nucleosome core particle. Which of the following histone proteins does not form part of the octameric core?

A.

H2A

B.

H1

C.

H4

D.

H3

Answer: Option B) H1

Explanation:

Histone refers to the family of five very basic positively charged polypeptides that are tightly associated with DNA in the chromosomes of all eukaryotic cells. These histones form the core of nucleosomes, around which DNA is wrapped. The major histones that form the octameric core are H2A, H2B, H3 and H4.

Thus, H1 is not a part of the octameric core.