One of the best pieces of evidence for the process of gene duplication and mutation

a serious mutation in ribosomal RNA gene is worse. the mutated ribosomes may lose their abilty to bind to messenger RNAs through Shine Dalgarno Sequences. they may also present wrongly placed E, P and A sites to the messenger RNA. this will lead to lethal results ranging from abnormal polypeptide formation to no formation at all.