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29 November, 16:54

How does mg2 + block the effect of extracellular calcium on neurotransmitter release?

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  1. 29 November, 20:22
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    Magnesium is a strong anode than calcium. So, Mg will be oxidized into Mg2+. So instead of having Ca being the reducing agent, Mg will takes its place. That's how the "Blocking" occur.

    Without Ca2+, no neurotransmitter was released because the exocytosis of the synaptic vesicles is dependent upon Ca2+.

    So, when magnesium is added to the extracellular fluid it blocks the calcium channels and inhibits the release of neurotransmitter.
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